Popović, Dušica J. Popović, Kosta J. Miljković, Dejan Lalošević, Dušan Dolićanin, Zana Čapo, Ivan Popović, Jovan K. info:eu-repo/semantics/conferenceProceedings All rights reserved application/pdf 765837 bytes 2023 JCMST 2023 - The 2nd PSU-UNS Joint Conference on Medical Science and Technology, 11-13 October 2023 Repurposed drug combinations that efficaciously inhibit fibrosarcoma induced by BHK-21/C13 in hamsters eng https://phaidrabg.bg.ac.rs/o:31330 Keywords : BHK-21/C13, repurposed drugs, fibrosarcoma, hamsters, NF-kB. Abstract: A large diversity in molecular mechanisms of cancer regulation allows some marketed pleiotropic non-oncological non-toxic pharmaceuticals to be used in oncology, what reduce duration and cost of novel anticancer treatment research. By docking data of biomolecular activities of nontoxic non-oncological drugs with anticancer targets, we have chosen some promising combinations for further screening on fibrosarcoma in hamsters and separated combinations for possible use in oncology. For each repurposed drug – component of efficacious combination, identification of known anticancer mechanisms was found in the literature and jointly compared.