o:31257 Expression of focal adhesion kinase microrna regulators is related to dedifferentiation in thyroid neoplasia spectrum Ekspresija mikroRNK regulatora fokalne adhezione kinaze povezana je sa dediferencijacijom u spektru tiroidne neoplazije en ABSTRACT The specter of malignant thyroid lesions comprises tumors with different degrees of differentiation, rendering the differential diagnosis and prognosis of these tumors challenging. Focal adhesion kinase (FAK) is a tyrosine kinase involved in cellular communication and locomotion, functioning as a hub in the interactome of focal adhesions. Its upregulation has been demonstrated in a number of tumor types including thyroid cancer. FAK is regulated on several levels, one of which includes posttranscriptional inhibition by microRNAs among which are miR-7-5p, miR-135a-5p, and miR-138-5p. Changes in the regulation of FAK can disturb its activation and indirectly influence malignant transformation and cancer progression. Focal adhesion kinase, microRNA, thyroid tumor 1552099 10.1530/endoabs.92.PS3-28-07 1552101 1470-3947 2023-10-19T08:59:53.091Z 44 yes 46 Valentina Ignjatović Jocić University of Belgrade, Institute for the Application of Nuclear Energy INEP, Serbia 0000-0002-9887-4237 Jelena Janković Miljuš University of Belgrade, Institute for the Application of Nuclear Energy INEP, Serbia doktor biohemijskih nauka person 0000-0002-2589-3306 Tijana Išić Denčić University of Belgrade, Institute for the Application of Nuclear Energy INEP, Serbia doktor bioloških nauka person 0000-0001-8475-2266 Vladan Živaljević Center for Endocrine Surgery, Institute of Endocrinology, Diabetes and Diseases of Metabolism, Clinical Center of Serbia, Belgrade, Serbia person Svetislav Tatić University of Belgrade, Institute of Pathology, Faculty of Medicine, Serbia, person Ilona Đorić University of Belgrade, Institute for the Application of Nuclear Energy INEP, Serbia doktor bioloških nauka person 0000-0001-5322-4559 Sonja Šelemetjev University of Belgrade, Institute for the Application of Nuclear Energy INEP, Serbia doktor bioloških nauka person 0000-0002-2898-6671 application/pdf 2348126 https://phaidrabg.bg.ac.rs/o:31257 no yes 16 70 92000004 11A29 11A2902 11A32 11A3240 Endocrine Abstracts-45th Annual Meeting of the European Thyroid Association (ETA) 2023 92 Bioscientifica 2023