Endocrine Abstracts-45th Annual Meeting of the European Thyroid Association (ETA) 2023 92 Thyroglobulin detection in extracellular vesicles isolated from human plasma thyroid cancer, extracellular vesicles, nanoparticle tracking analysis http://creativecommons.org/licenses/by/4.0/legalcode info:eu-repo/semantics/conferenceProceedings Đorić, Ilona Janković Miljuš, Jelena Kosanović, Maja Išić Denčić, Tijana Živaljević, Vladan Šelemetjev, Sonja ABSTRACT Detecting recurrence of differentiated thyroid cancer is performed by serial measurements of serum thyroglobulin (Tg) levels, however, in the presence of anti-Tg antibodies, this measurement is unreliable. Extracellular vesicles (EVs) are small membrane-enclosed structures, with a prominent role in cell-to-cell communication. All cell types release EVs and they can be isolated from various biofluids, while their cargo reflects the content of the cell of origin. Previous studies showed that EVs from bovine serum, FRTL-6 rat thyroid cell line conditioned medium and human urine all contain thyroglobulin. EVs isolated from human serum were not previously investigated for the presence of Tg. application/pdf 2348126 bytes 2023 Bioscientifica eng https://phaidrabg.bg.ac.rs/o:31256 doi:10.1530/endoabs.92.PS2-19-08 ISSN: 1470-3947