o:31254 Overexpression of activated focal adhesion kinase correlates with adverse clinicopathological factors of papillary thyroid carcinoma Povećana ekspresija aktivirane fokalne adhezione kinaze koreliše sa nepovoljnim kliničko-patološkim faktorima papilarnog karcinoma štitaste žlezde en ABSTRACT Focal adhesion kinase (FAK) is non-receptor tyrosine kinase that has been shown to affect cell motility, adhesion, invasion, cell survival, proliferation and dedifferentiation. Its increased expression has been reported for various types of malignancies and is associated with cancer progression. However, there are less information regarding its posttranslational form, phosphorylated at Tyrosine 397 (pY397-FAK), which represents a key event for complete protein activation. In order to determine the possible role of the activated form of FAK in progression of papillary thyroid carcinoma (PTC), we analyzed expression levels of pY397-FAK. We aimed to investigate its presence in tumor and adjacent normal thyroid tissue and its localization in tumor cells, as well as its expression levels in relation to clinicopathological parameters of PTC patients. Focal adhesion kinase, papillary thyroid carcinoma 1552099 10.1530/endoabs.92.PS1-09-08 1552101 1470-3947 2023-10-19T07:55:44.700Z 44 yes 46 Valentina Ignjatović Jocić University of Belgrade, Institute for the Application of Nuclear Energy INEP, Serbia 0000-0002-9887-4237 Jelena Janković Miljuš University of Belgrade, Institute for the Application of Nuclear Energy INEP, Serbia doktor biohemijskih nauka person 0000-0002-2589-3306 Jelena Rončević University of Belgrade, Institute for the Application of Nuclear Energy INEP, Serbia person 0000-0003-3656-6420 Svetislav Tatić University of Belgrade, Institute of Pathology, Faculty of Medicine, Serbia person Tijana Išić Denčić University of Belgrade, Institute for the Application of Nuclear Energy INEP, Serbia doktor bioloških nauka person 0000-0001-8475-2266 Ilona Đorić University of Belgrade, Institute for the Application of Nuclear Energy INEP, Serbia doktor bioloških nauka person 0000-0001-5322-4559 Sonja Šelemetjev University of Belgrade, Institute for the Application of Nuclear Energy INEP, Serbia doktor bioloških nauka person 0000-0002-2898-6671 application/pdf 2348126 https://phaidrabg.bg.ac.rs/o:31254 no yes 16 70 92000004 11A29 11A2902 11A32 11A3240 Endocrine Abstracts-45th Annual Meeting of the European Thyroid Association (ETA) 2023 92 Bioscientifica 2023