info:eu-repo/semantics/conferenceProceedings Ignjatović Jocić, Valentina Janković Miljuš, Jelena Rončević, Jelena Tatić, Svetislav Išić Denčić, Tijana Đorić, Ilona Šelemetjev, Sonja ABSTRACT Focal adhesion kinase (FAK) is non-receptor tyrosine kinase that has been shown to affect cell motility, adhesion, invasion, cell survival, proliferation and dedifferentiation. Its increased expression has been reported for various types of malignancies and is associated with cancer progression. However, there are less information regarding its posttranslational form, phosphorylated at Tyrosine 397 (pY397-FAK), which represents a key event for complete protein activation. In order to determine the possible role of the activated form of FAK in progression of papillary thyroid carcinoma (PTC), we analyzed expression levels of pY397-FAK. We aimed to investigate its presence in tumor and adjacent normal thyroid tissue and its localization in tumor cells, as well as its expression levels in relation to clinicopathological parameters of PTC patients. application/pdf 2348126 bytes Endocrine Abstracts-45th Annual Meeting of the European Thyroid Association (ETA) 2023 92 Overexpression of activated focal adhesion kinase correlates with adverse clinicopathological factors of papillary thyroid carcinoma Focal adhesion kinase, papillary thyroid carcinoma http://creativecommons.org/licenses/by/4.0/legalcode eng https://phaidrabg.bg.ac.rs/o:31254 doi:10.1530/endoabs.92.PS1-09-08 ISSN: 1470-3947 Bioscientifica 2023