o:31186 Procena uticaja paratiroidektomije na kvalitet života pacijenata sa primarnim asimptomatskim hiperparatiroidizmom doktorska disertacija The impact of parathyroidectomy on the quality of life of patients with primary asymptomatic hyperparathyroidism : doctoral dissertation sr UvodPrimarni hiperparatiroidizam (pHPT) predstavlja endokrinološki poremećaj metabolizmakalcijuma, sa hiperkalcemijom i povišenim ili neadekvatno normalnim koncentracijamaparatiroidnog hormona (PTH). Najčešći je uzrok hiperkalcemije u opštoj populaciji. Jedinitrajni način lečenja je operativni. Pored tipičnih kliničkih simptoma, pHPT je povezan i sanarušenim kvalitetom života i kognitivnim statusom.Iz tog razloga je cilj ove studije da ispita da li postoji razlika u kvalitetu života i kognitivnimfunkcijama kod osoba sa asimptomatskim primarnim hiperparatiroidizmom pre i posleparatiroidektomije. Kao drugi cilj ove studije je identifikacija nezavisnih faktora koji utiču nakvalitet života i kognitivne funkcije osoba sa asimptomatskim primarnimhiperparatiroidizmom.Materijal i metodeSprovedena je panel studija u Centru za endokrinu hirurgiju Klinike za endokrinologiju,dijabetes i bolesti metabolizma Kliničkog centra Srbije (CEH KCS) u periodu od 2014. do2017. godine. Studijom su obuhvaćeni pacijenti sa novootkrivenim primarnimhiperparatiroidizmom kojima je indikovana paratiroidektomija. Kriterijumi za uključivanje ustudiju su dijagnoza asimptomatskog pHPT, stariji od 18 godina, bez prethodne operacije naparatiroidnim žlezdama, nivo serumskog kalcijuma preko 2,65 mmol/L i PTH preko 65pg/mL. Kriterijumi za isključivanje su simptomatske forme pHPT, sekundarne forma HPT,ostali uzroci hiperkalcemije. Prikupljeni su osnovni demografski i klinički podaci o bolesti.Procena kvaliteta života i neurokognitivnog statusa sprovedena je putem intervjua preoperacije, kao i posle prvog i šestog meseca od operacije... NTRODUCTIONPrimary hyperparathyroidism (pHPT) represents an endocrine disorder of calciummetabolism, which presents with hypercalcemia and elevated or inappropriately normalconcentrations of parathyroid hormone (PTH). PHPT is the most common cause ofhypercalcemia in the general population, and surgery represents the only permanent treatmentmethod. Besides typical clinical symptoms, pHPT may also be associated with poor quality oflife and impaired cognitive status. Thus, the primary aim of the present study was to assesswhether there is a difference in the quality of life and cognitive status in patients with anasymptomatic pHPT before and after parathyroidectomy. The second objective was toidentify independent factors that affect the quality of life and cognitive functions in patientswith asymptomatic pHPT.MATERIALS AND METHODSBetween 2014 and 2017, a panel study was conducted at the Center for Endocrine Surgery ofthe Clinic for Endocrinology, Diabetes, and Metabolic Diseases of the Clinical Center ofSerbia. The study included patients with newly diagnosed asymptomatic primaryhyperparathyroidism in whom parathyroidectomy was indicated, older than 18 years, withoutprevious surgery on the parathyroid glands, with serum calcium level over 2.65 mmol/L andPTH level over 65 pg/mL. Patients with symptomatic forms of pHPT, secondary forms ofHPT, and other causes of hypercalcemia were excluded from the study. Basic demographicdata of interest and relevant clinical data were collected. Quality of life and neurocognitivestatus were assessed in interviews before surgery, one month, and six months followingsurgery... Medicina - Epidemiologija / Medicine - Epidemiology Datum odbrane: 26.09.2023. primarni hiperparatiroidizam; paratiroidektomija; kvalitet života; depresija; anksioznost; stres primary hyperparathyroidism; parathyroidectomy; quality of life; depression; anxiety; stress 616.447-008.61-089:85:616.8(043.3) 91552100 127300873 91552101 9243 2023-10-17T12:04:39.053Z 45 no 46 Milan, 1986- Jovanović 62899465 2023 63 mentor Ivan, 1955- Paunović 12442727 2023 63 komentor Sandra, 1965- Šipetić-Grujičić 12686695 2023 63 član komisije Vladan, 1967- Živaljević 12754279 2023 63 član komisije Darija, 1975- Kisić-Tepavčević 12892519 2023 63 član komisije Otaš, 1971- Durutović 2385511 2023 63 član komisije Rastko, 1973- Živić 22027623 2023 63 član komisije Božidar, 1968- Odalović 64780809 2023 169, [24] str. 3697229 http://phaidrabg.bg.ac.rs/o:31186 no yes 12 2023-10-17T12:04:39.320Z 70 11 1066950 1066999 primarni hiperparatiroidizam; paratiroidektomija; kvalitet života; depresija;anksioznost; stres primary hyperparathyroidism; parathyroidectomy; quality of life; depression;anxiety; stress 616.447-008.61-089:85:616.8(043.3) 1738 11A32 2023