o:30987 Phospholipid liposomes as a carrier for Aloe vera waste extract en ABSTRACT Aloe vera L. leaf waste contains biologically active compounds, including polyphenols, anthraglycosides, free anthraquinones, resins, mono- and polysaccharides, polypeptides, terpenoids, sterols, chromones, lectins, fatty, amino and organic acids, enzymes, saponins, vitamins, and minerals. However, the application of the mentioned bioactive components is rather limited because of their low solubility, stability, integrity, permeability, and consequently bioavailability. Thus, the encapsulation of the active principles of A. vera into liposomes can be advantageous. In the present study, A. vera waste extract-loaded liposomes were developed and characterized via the determination of particle size, polydispersity index (PDI), zeta potential, conductivity, mobility, storage stability, density, surface tension, and viscosity. The particle size of liposomes with A. vera extract amounted to 335.0±20.5 nm, while the PDI was 0.505±0.056. The zeta potential, conductivity, and mobility were 1.81±0.32 mV, 0.485±0.013 mS/cm, and 0.142±0.026 µmcm/Vs, respectively. The vesicle size and PDI changed during 21 days of storage. The zeta potential, conductivity, and mobility did not vary in the liposomal suspension during the stability study. The density, surface tension, and viscosity were 0.991±0.003 g/mL, 22.8±0.2 mN/m, and 22.9±0.1 mPa·s, respectively. The beneficial effects of bioactive principles from A. vera on human health highlight the application of liposomes as a carrier for A. vera leaf waste extract and their potential implementation in food, functional food, pharmaceutical, and cosmetic formulations. Aloe vera, encapsulation, extract, liposomes, waste 1552100 978-86-6305-137-9 2023-10-03T09:25:28.063Z 44 yes 46 Aleksandra A. Jovanović University of Belgrade, Institute for the Application of Nuclear Energy, Serbia doktor tehnoloških nauka 0000-0001-5394-0125 Muna Rajab Elferjane University of Belgrade, Faculty of Technology and Metallurgy, Serbia person Marija Gnjatović University of Belgrade, Institute for the Application of Nuclear Energy INEP, Serbia person Aleksandar Marinković University of Belgrade, Faculty of Technology and Metallurgy, Serbia person Branko Bugarski University of Belgrade, Faculty of Technology and Metallurgy, Serbia person application/pdf 947050 https://phaidrabg.bg.ac.rs/o:30987 no yes 1 70 92000004 11A29 11A41 30th International Conference Ecological Truth and Environmental Research – EcoTER’23 - Proceedings 438 University of Belgrade, Technical Faculty in Bor 2023