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    <ns1:title language="en">ROS and NF-kB role in repurposed drugs treatment of hamster fibrosarcoma</ns1:title>
    <ns1:language>en</ns1:language>
    <ns1:description language="sr">Abstract: The NF-kB activity in cancer cells promotes tumor growth by stimulation of cell proliferation, neoangiogenesis and by inhibition of apoptosis and ROS activity. 
Anticancer combinations of two repurposed drugs: metformin with 2-Deoxy-D-glucose, deoxycholic acid, caffeine, itraconazole or disulfiram (&lt;50% LD50, equivalent to usual human dose) mechanism of action was investigated by rescuing treated BHK-21/C13 fibrosarcoma growth in hamsters with ROS inhibitor nitroglycerin and NF-kB stimulator mebendazole. 19 days after inoculation, anticancer effects were assessed by biophysical measurements of fibrosarcoma growth and immunohistochemical markers of tumor proliferation (Ki-67, PCNA), neoangiogenesis (CD34, CD31), glucose metabolism (GLUT1), NO metabolism (iNOS) and apoptosis (COX4, Cytochrome C). 
The combinations have shown significant antitumor effects (P&lt;0.05) which were inhibited partly by addition of ROS inhibitor nitroglycerin and completely by NF-kB stimulator mebendazole. 
Results indicate NF-kB key role in anticancer action of investigated drug combinations of non-oncological drugs and their potential to be used in oncology.
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      <ns2:identifier>ISBN 978-86-7220-140-6 (FOC)</ns2:identifier>
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        <ns3:firstname>Kosta J.</ns3:firstname>
        <ns3:lastname>Popović</ns3:lastname>
        <ns3:institution> Faculty of Medicine, University of Novi Sad</ns3:institution>
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        <ns3:firstname>Dušica J.</ns3:firstname>
        <ns3:lastname>Popović</ns3:lastname>
        <ns3:institution>Državni univerzitet u Novom Pazaru</ns3:institution>
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        <ns3:lastname>Miljković</ns3:lastname>
        <ns3:institution>Faculty of Medicine University Novi Sad</ns3:institution>
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        <ns3:firstname>Dušan</ns3:firstname>
        <ns3:lastname>Lalošević</ns3:lastname>
        <ns3:institution>Faculty of Medicine of Novi Sad</ns3:institution>
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        <ns3:orcid>0000-0002-7739-5202</ns3:orcid>
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        <ns3:institution>Faculty of Medicine University Novi Sad</ns3:institution>
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        <ns3:firstname>Mihalj</ns3:firstname>
        <ns3:lastname>Poša</ns3:lastname>
        <ns3:institution>Faculty of Medicine University Novi Sad</ns3:institution>
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        <ns3:firstname>Jovan K.</ns3:firstname>
        <ns3:lastname>Popović</ns3:lastname>
        <ns3:institution>Faculty of Medicine University Novi Sad</ns3:institution>
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        <ns3:institution>Državni univerzitet u novom pazaru</ns3:institution>
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    <ns12:name_magazine language="en">Serbian Biochemical Society Twelfth Conference, International scientific meeting &quot;Biochemistry in Biotechnology&quot; 21-23.09.2023. Belgrade, Serbia. Proceedings. p. 79 (M34)</ns12:name_magazine>
    <ns12:volume>12</ns12:volume>
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    <ns12:publisher>Twelfth Conference, International scientific meeting &quot;Biochemistry in Biotechnology&quot; 21-23.09.2023. Belgrade, Serbia. </ns12:publisher>
    <ns12:releaseyear>2023</ns12:releaseyear>
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