o:30764 Pumpkin pulp extracts from a Serbian Cucurbita maxima Breeding Collection: Phenol profile and in vitro bioactivity Ekstrakti pulpe bundeve srpskih sorti Cucurbita maxima: Fenolni profil i in vitro bioaktivnost en ABSTRACT Methanolic pulp extracts from the four selected Serbian accessions of Cucurbita maxima were evaluated for phenol profile cytotoxic effects and antimicrobial activity. The results revealed that quinic acid and amentoflavone were the most abundant phenols. The extracts increased the viability of HTR-8 SV/Neo, JEG-3, JAR cells, with the most pronounced increase in the treatment with MAX 113 extract. Furthermore, in HeLa cells, the extracts showed a modest cytotoxic effect. The antimicrobial effects evaluation showed that out of four pumpkin extracts, MAX 117 could moderately suppress the growth of Staphylococcus aureus and Staphylococcus epidermidis (MIC=1000 µg/mL). The observed biological effects indicate the potential medicinal properties of these pumpkin extracts and contribute to the varietal selection of the most suitable accessions in national breeding programs as candidates for improving human health. Pumpkin, Phenolics, Antiproliferative activity, Antimicrobial activity, Functional food 1552099 10.1016/j.focha.2023.100395 2023-09-08T13:03:18.403Z 44 yes 46 Sanja Krstić Institute of Pharmaceutical Sciences, University of Graz, Austria Milorad Miljić Institute of Pharmaceutical Sciences, University of Graz, Austria person Jelena Antić-Stanković University of Belgrade, Faculty of Pharmacy, Department of Microbiology and Immunology, Serbia person Dragana D. Božić University of Belgrade, Faculty of Pharmacy, Department of Microbiology and Immunology, Serbia person Milica Jovanović Krivokuća University of Belgrade, Institute for the Application of Nuclear Energy INEP, Serbia doktor bioloških nauka person 0000-0001-8292-4853 Andrea Pirković University of Belgrade, Institute for the Application of Nuclear Energy INEP, Serbia doktor bioloških nauka person 0000-0002-1182-4895 application/pdf 62160 https://phaidrabg.bg.ac.rs/o:30764 no yes 18 70 92000001 11A13 11A1314 11A29 11A2901 Food Chemistry Advances 3 Elsevier 2023