o:30746 Myasthenia gravis treated in the neurology intensive care unit: a 14-year single centre experience en ABSTRACT Background and aims: Severe myasthenia gravis (MG) exacerbation with respiratory failure and/or dysphagia usually require monitoring and treatment in the Neurology Intensive Care Unit (NICU). The aim of our study was to identify all patients with severe MG exacerbation treated in the NICU in order to assessed potential factors affecting patients’ need for mechanical ventilation, occurrence of complications and the final outcome. Methods: We retrospectively included all patients with severe exacerbation of MG who required management in the NICU during a 14-year period. Baseline sociodemographic and clinical features, data on medication, comorbidities, and outcome were obtained by reviewing medical records and institutional databases. Results: Our study comprised 130 severe MG exacerbations detected in 118 patients. Median age of patients was 61.5 years and women accounted for 58.5% of the patients. Half of the patients required mechanical ventilation during hospitalization. Lethal outcome was observed in 12.3% of severe MG exacerbations. Only elder age was an independent negative predictor of survival (OR 0.89, 95% CI 0.82–0.97, p<0.01). Complications during hospitalization were detected in 50% of patients. A higher number of comorbidities (OR 1.09, 95% CI 1.60–2.35, p=0.01) and mechanical ventilation (OR 28.48, 95% CI 8.56–94.81, p<0.01) were independent predictors of complications during hospitalization. Conclusion: Patients with a severe MG exacerbation who do not require mechanical ventilation have a good outcome after treatment in the NICU. Elder age is an independent predictor of lethal outcome in patients with severe MG exacerbation. Mechanical ventilation and a higher number of comorbidities lead to more frequent complications. 1552101 1468-1331 (202206)29:6+1 2023-09-07T10:44:25.751Z 44 yes 46 Mirjana Ždraljević Neurology Clinic, University Clinical Center of Serbia, Belgrade, Serbia Stojan Perić Neurology Clinic, University Clinical Center of Serbia, Belgrade, Serbia person Marta Jeremić Neurology Clinic, University Clinical Center of Serbia, Belgrade, Serbia person Dragana Lavrnić Neurology Clinic, University Clinical Center of Serbia, Belgrade, Serbia person Ivana Basta Neurology Clinic, University Clinical Center of Serbia, Belgrade, Serbia person Ljiljana Hajduković University of Belgrade, Institute for the Application of Nuclear Energy INEP, Serbia doktor biohemijskih nauka person 0000-0003-0720-2345 Dejana R. Jovanović Neurology Clinic, University Clinical Center of Serbia, Belgrade, Serbia person Ivana Berisavac Neurology Clinic, University Clinical Center of Serbia, Belgrade, Serbia person application/pdf 33979340 https://phaidrabg.bg.ac.rs/o:30746 no yes 1 70 92000004 11A29 11A2903 European Journal of Neurology-Abstracts of the 8th Congress of the European Academy of Neurology 29 Supplement 1 2022