
<ns0:uwmetadata xmlns:ns0="http://phaidra.univie.ac.at/XML/metadata/V1.0" xmlns:ns1="http://phaidra.univie.ac.at/XML/metadata/lom/V1.0" xmlns:ns10="http://phaidra.univie.ac.at/XML/metadata/provenience/V1.0" xmlns:ns11="http://phaidra.univie.ac.at/XML/metadata/provenience/V1.0/entity" xmlns:ns12="http://phaidra.univie.ac.at/XML/metadata/digitalbook/V1.0" xmlns:ns13="http://phaidra.univie.ac.at/XML/metadata/etheses/V1.0" xmlns:ns2="http://phaidra.univie.ac.at/XML/metadata/extended/V1.0" xmlns:ns3="http://phaidra.univie.ac.at/XML/metadata/lom/V1.0/entity" xmlns:ns4="http://phaidra.univie.ac.at/XML/metadata/lom/V1.0/requirement" xmlns:ns5="http://phaidra.univie.ac.at/XML/metadata/lom/V1.0/educational" xmlns:ns6="http://phaidra.univie.ac.at/XML/metadata/lom/V1.0/annotation" xmlns:ns7="http://phaidra.univie.ac.at/XML/metadata/lom/V1.0/classification" xmlns:ns8="http://phaidra.univie.ac.at/XML/metadata/lom/V1.0/organization" xmlns:ns9="http://phaidra.univie.ac.at/XML/metadata/histkult/V1.0">
  <ns1:general>
    <ns1:identifier>o:29958</ns1:identifier>
    <ns1:title language="en">Extremely low-frequency electromagnetic field induces a change in proliferative capacity and redox homeostasis of human lung fibroblast cell line MRC-5</ns1:title>
    <ns1:language>en</ns1:language>
    <ns1:description language="en">Abstract: Numerous studies have shown that extremely low-frequency electromagnetic field (ELF-EMF) by modulating oxidativeantioxidative
balance in the cells achieved beneficial and harmful effects on living organisms. The aim of this study was to
research changes of both proliferative capacity and redox homeostasis of human lung fibroblast cell lineMRC-5 during exposure
to ELF-EMF (50 Hz). The human lung fibroblast cell lineMRC-5 were exposed to ELF-EMF once a day in duration of 1 h during
24 h (1 treatment 1 h/day), 48 h (2 treatments 1 h/day), 72 h (3 treatments 1 h/day), and 7 days (7 treatments 1 h/day). After 24 h of
the last treatment, the proliferative capacity of the cells and the concentrations and activities of the components of the oxidative/
antioxidative system were determined: superoxide anion (O2
.−), hydrogen peroxide (H2O2), nitric oxide (NO), peroxynitrite
(ONOO−), reduced glutathione (GSH), oxidized glutathione (GSSG), superoxide dismutase (SOD), catalase (CAT), glutathione
peroxidase (GSH-Px), glutathione reductase (GR), and glutathione-S-transferase (GST). The results of this study show that ELFEMF
may affect a cell cycle regulation of human lung fibroblast cell lineMRC-5 through modulation of oxidative/antioxidative
defense system. The effects of ELF-EMF on proliferation and redox balance of human lung fibroblast cell lineMRC-5 depend on
exposure time. 
</ns1:description>
    <ns1:keyword language="en">Keywords: Electromagnetic field, Redox homeostasis, Cell proliferation, Human lung fibroblasts</ns1:keyword>
    <ns2:identifiers>
      <ns2:resource>1552099</ns2:resource>
      <ns2:identifier>10.1007/s11356-020-10039-0</ns2:identifier>
    </ns2:identifiers>
    <ns2:identifiers>
      <ns2:resource>1552101</ns2:resource>
      <ns2:identifier>0944-1344</ns2:identifier>
    </ns2:identifiers>
  </ns1:general>
  <ns1:lifecycle>
    <ns1:upload_date>2023-06-02T11:15:00.692Z</ns1:upload_date>
    <ns1:status>44</ns1:status>
    <ns2:peer_reviewed>no</ns2:peer_reviewed>
    <ns1:contribute seq="0">
      <ns1:role>46</ns1:role>
      <ns1:entity seq="0">
        <ns3:firstname>Maida </ns3:firstname>
        <ns3:lastname>Leković</ns3:lastname>
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        <ns3:firstname>Nerkesa </ns3:firstname>
        <ns3:lastname>Dreković</ns3:lastname>
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      <ns1:entity seq="2">
        <ns3:firstname>Nihat </ns3:firstname>
        <ns3:lastname>Granica</ns3:lastname>
        <ns3:type>person</ns3:type>
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      <ns1:entity seq="3">
        <ns3:firstname> Elvis </ns3:firstname>
        <ns3:lastname>Mahmutović</ns3:lastname>
        <ns3:institution>Državni univerzitet u Novom Pazaru</ns3:institution>
        <ns3:type>person</ns3:type>
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        <ns3:orcid>0000-0003-1849-868X</ns3:orcid>
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        <ns3:firstname>Natasa </ns3:firstname>
        <ns3:lastname>Djordjević</ns3:lastname>
        <ns3:institution>Državni univerzitet u Novom Pazaru</ns3:institution>
        <ns3:type>person</ns3:type>
        <ns3:conor>14042215</ns3:conor>
        <ns3:orcid>0000-0002-1100-5689</ns3:orcid>
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  <ns1:technical>
    <ns1:format>application/pdf</ns1:format>
    <ns1:size>482130</ns1:size>
    <ns1:location>https://phaidrabg.bg.ac.rs/o:29958</ns1:location>
  </ns1:technical>
  <ns1:rights>
    <ns1:cost>no</ns1:cost>
    <ns1:copyright>yes</ns1:copyright>
    <ns1:license>1</ns1:license>
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  <ns1:classification>
    <ns1:purpose>70</ns1:purpose>
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  <ns1:organization>
    <ns8:hoschtyp>92000001</ns8:hoschtyp>
    <ns8:orgassignment>
      <ns8:faculty>20A01</ns8:faculty>
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  <ns12:digitalbook>
    <ns12:name_magazine language="en">Environmental Science and Pollution Research</ns12:name_magazine>
    <ns12:booklet>27</ns12:booklet>
    <ns12:from_page>39466</ns12:from_page>
    <ns12:to_page>39473</ns12:to_page>
    <ns12:releaseyear>2020</ns12:releaseyear>
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