o:29815 Significance of 1,25-dihydroxyvitamin D3 on overall mortality in peritoneal dialysis patients with COVID-19 Značaj 1,25-dihidroksi-vitamina D3 za ukupnu smrtnost kod pacijenata na peritoneumskoj dijalizi obolelih od COVID-19 en ABSTRACT In previous publications, we pointed out the importance of mannosylation of fibrinogen for the development of cardiovascular complications and fucosylation as a predictor of peritoneal membrane dysfunction in patients on peritoneal dialysis (PD). After a follow-up period of 30 months from the onset of the COVID-19 pandemic, we evaluated the significance of 1,25-dihydroxyvitamin D3 (calcitriol) therapy, primary disease, biochemical and hematologic analyzes, and previously performed glycan analysis by lectin-based microarray as predictors of mortality in this patient group. After univariate Cox regression analysis, diabetes mellitus (DM) and calcitriol therapy were found to be potential predictors of mortality. Additional multivariate Cox regression analysis confirmed that only DM was a predictor of mortality. Nevertheless, the use of calcitriol in therapy significantly reduced mortality in this patient group, as shown by the Kaplan–Meier survival curve. The presence of DM as a concomitant disease proved to be a strong predictor of fatal outcome in PD patients infected with SARS-CoV-2. This is the first study to indicate the importance and beneficial effect of calcitriol therapy on survival in PD patients with COVID-19 infection. In addition, this study points to the possibility that adverse thrombogenic events observed in PD patients during the pandemic may be caused by aberrant fibrinogen glycosylation. calcitriol, COVID-19, peritoneal dialysis, glycosylation, mortality 1552099 10.3390/nu15092050 2023-05-25T14:14:45.414Z 44 yes 46 Marko Baralić University of Belgrade, School of Medicine, Serbia Dragana Robajac University of Belgrade, Institute for the Application of Nuclear Energy INEP, Serbia doktor biohemijskih nauka person 0000-0002-6423-4645 Ana Penezić University of Belgrade, Institute for the Application of Nuclear Energy INEP, Serbia doktor biohemijskih nauka person 0000-0002-2539-4507 Voin Brković University of Belgrade, School of Medicine, Serbia person Nikola Gligorijević University of Belgrade, Institute of Chemistry, Technology and Metallurgy, Serbia person Ana Bontić University of Belgrade, School of Medicine, Serbia person Jelena Pavlović University of Belgrade, School of Medicine, Serbia person Jelena Nikolić University Clinical Centre of Serbia, Clinic of Nephrology, Belgrade, Serbia person Goran Miljuš University of Belgrade, Institute for the Application of Nuclear Energy INEP, Serbia doktor biohemijskih nauka person 0000-0001-6417-8711 Zorana Dobrijević University of Belgrade, Institute for the Application of Nuclear Energy INEP, Serbia doktor bioloških nauka person 0000-0002-4652-7719 Miloš Šunderić University of Belgrade, Institute for the Application of Nuclear Energy INEP, Serbia doktor biohemijskih nauka person 0000-0002-0940-9481 Lucia Pažitna Slovak Academy of Sciences, Institute of Chemistry, Bratislava, Slovakia person Jaroslav Katrlik Slovak Academy of Sciences, Institute of Chemistry, Bratislava, Slovakia person Olgica Nedić University of Belgrade, Institute for the Application of Nuclear Energy INEP, Serbia doktor biohemijskih nauka person 0000-0003-2042-0056 Mirjana Laušević University of Belgrade, School of Medicine, Serbia person application/pdf 496996 https://phaidrabg.bg.ac.rs/o:29815 no yes 16 70 92000001 11A32 11A29 11A2905 11A24 Nutrients 15 9 MDPI 2023