o:29656 Association of vitamin D receptor genetic variants with bone mineral density and inflammatory markers in rheumatoid arthritis en Abstract: Background and aims Vitamin D receptor (VDR) genetic variants are considered to have a role in the pathogenesis of rheumatoid arthritis (RA). This study examines an association of FokI, BsmI, ApaI and TaqI with RA, as well as with bone mineral density (RA with normal bone mineral density, RA-NBMD; RA with associated osteopenia, RA-OSTP; and RA with associated osteoporosis, RA-OP) and inflammatory markers. Materials and methods VDR genetic variants were tested in 248 subjects using the PCR-RFLP method. Results Significant differences were observed in the distribution of FokI genotypes between RA patients (p < 0.001), or subgroups (RA-NBMD, RA-OSTP, RA-OP) (p = 0.035, p = 0.02, p < 0.001, respectively) and controls. Prevalence of FokI f allele was significantly higher in RA group (p < 0.001) and subgroups (p = 0.003, p = 0.021, p < 0.001, respectively) compared to controls. An increased susceptibility to RA-OSTP was revealed in BsmI/ApaI Ba (AC) haplotype carriers (p = 0.012). A significantly higher erythrocyte sedimentation rate values were obtained in FokI FF compared to Ff + ff carriers (54.57 ± 23.73 vs. 22.83 ± 12.42; p < 0.001) within the RA-NBMD subgroup. Conclusion The results of the study indicate an association of RA with FokI genetic variant and increased susceptibility to RA in f allele carriers, as well as to RA-OSTP in BsmI/ApaI Ba (AC) haplotype carriers. Keywords: Rheumatoid arthritis Vitamin D receptor Single nucleotide polymorphism Bone mineral density Inflammatory markers 1552099 10.1016/j.clinbiochem.2020.10.006 1552101 0009-9120 2023-05-19T12:59:24.469Z 44 no 46 Milena Despotović 0000-0001-7436-3398 Tatjana Jevtović-Stoimenov person 0000-0003-0600-5411 Sonja Stojanović person 0000-0001-6914-6284 Jelena Bašić person 0000-0002-9221-561X Jasen Kundalić person 0000-0002-4377-9283 Branka Đorđević person 0000-0002-4521-1253 Milica Ranđelović person Dusica Pavlović Državni univerzitet u Novom Pazaru person 0000-0003-1604-8853 application/pdf 515753 https://phaidrabg.bg.ac.rs/o:29656 no yes 18 70 92000001 20A01 Clinical Biochemistry 87 26 31 2021