o:28780 Reaction of a 3-aryilidene-2-thiohydantoin derivative with polymeric trans-[CuCl2(DMSO)2]n complex: unexpected isomerization to dinuclear cis-[{CuCl(DMSO)2}(μ-Cl)]2 en Abstract: The 3-arylidene-2-thiohydantoin derivative, 3-[(2-hydroxybenzylidene) amino]-2-thioxoimidazolidin-4-one, was synthesized in a two-step condensation reaction of 2-hydroxybenzaldehyde, thiosemicarbazide and ethyl chloroacetate. The ligand was structurally characterized by NMR and IR spectroscopy, as well as by elemental analysis. In the reaction of the well-known polymeric trans-[CuCl2(DMSO)2]n complex with the polydentate thiohydantoin type ligand, instead of the corresponding copper thiohydantoin complex, unexpectedly, the dinuclear cis-[{CuCl(DMSO)2}(μ-Cl)]2 complex (1) was formed predominantly as the final stable product. The structure of the complex 1 was confirmed by single crystal X-ray diffraction analysis. The cis-complex is obtained through assisted isomerization of the trans-form, in which the thiohydantoin derivative has a crucial role. Keywords: Cu(II) complex; spectroscopic characterization; single crystal X-ray analysis; antimicrobial activity 1552099 10.2298/JSC200917060S 1552101 0352-5139 2023-04-12T10:12:56.604Z 44 no 46 Tanja Soldatović 0000-0003-3010-6503 Petar B. Stanić person Marko V. Rodić person Aleksandar B. Pavić person Nataša S. Radaković person Biljana M. Šmit person Marija D. Živković person application/pdf 2744075 https://phaidrabg.bg.ac.rs/o:28780 no yes 1 70 92000001 20A01 Journal of the Serbian Chemical Society – version electronic 85 12 1591 1603 2020