https://phaidrabg.bg.ac.rs/o:28780 doi:10.2298/JSC200917060S ISSN: 0352-5139 Journal of the Serbian Chemical Society – version electronic 85(12) Soldatović, Tanja Stanić, Petar B. Rodić, Marko V. Pavić, Aleksandar B. Radaković, Nataša S. Šmit, Biljana M. Živković, Marija D. application/pdf 2744075 bytes eng 2020 Reaction of a 3-aryilidene-2-thiohydantoin derivative with polymeric trans-[CuCl2(DMSO)2]n complex: unexpected isomerization to dinuclear cis-[{CuCl(DMSO)2}(μ-Cl)]2 info:eu-repo/semantics/article Abstract: The 3-arylidene-2-thiohydantoin derivative, 3-[(2-hydroxybenzylidene) amino]-2-thioxoimidazolidin-4-one, was synthesized in a two-step condensation reaction of 2-hydroxybenzaldehyde, thiosemicarbazide and ethyl chloroacetate. The ligand was structurally characterized by NMR and IR spectroscopy, as well as by elemental analysis. In the reaction of the well-known polymeric trans-[CuCl2(DMSO)2]n complex with the polydentate thiohydantoin type ligand, instead of the corresponding copper thiohydantoin complex, unexpectedly, the dinuclear cis-[{CuCl(DMSO)2}(μ-Cl)]2 complex (1) was formed predominantly as the final stable product. The structure of the complex 1 was confirmed by single crystal X-ray diffraction analysis. The cis-complex is obtained through assisted isomerization of the trans-form, in which the thiohydantoin derivative has a crucial role. All rights reserved Keywords: Cu(II) complex; spectroscopic characterization; single crystal X-ray analysis; antimicrobial activity