o:28418 Food antioxidants and their interaction with human proteins Antioksidanti iz hrane i njihova interakcija sa humanim proteinima en ABSTRACT Common to all biological systems and living organisms are molecular interactions, which may lead to specific physiological events. Most often, a cascade of events occurs, establishing an equilibrium between possibly competing and/or synergistic processes. Biochemical pathways that sustain life depend on multiple intrinsic and extrinsic factors contributing to aging and/or diseases. This article deals with food antioxidants and human proteins from the circulation, their interaction, their effect on the structure, properties, and function of antioxidant-bound proteins, and the possible impact of complex formation on antioxidants. An overview of studies examining interactions between individual antioxidant compounds and major blood proteins is presented with findings. Investigating antioxidant/protein interactions at the level of the human organism and determining antioxidant distribution between proteins and involvement in the particular physiological role is a very complex and challenging task. However, by knowing the role of a particular protein in certain pathology or aging, and the effect exerted by a particular antioxidant bound to it, it is possible to recommend specific food intake or resistance to it to improve the condition or slow down the process. food antioxidants, human proteins, binding, interaction detection 1552099 10.3390/antiox12040815 1552101 2076-3921 2023-03-28T12:45:49.492Z 44 yes 46 Olgica Nedić University of Belgrade, Institute for the Application of Nuclear Energy INEP, Serbia doktor biohemijskih nauka 0000-0003-2042-0056 Ana Penezić University of Belgrade, Institute for the Application of Nuclear Energy INEP, Serbia doktor biohemijskih nauka person 0000-0002-2539-4507 Simeon Minić University of Belgrade, Faculty of Chemistry, Center of Excellence for Molecular Food Sciences, Department of Biochemistry, Serbia person Mirjana Radomirović University of Belgrade, Faculty of Chemistry, Center of Excellence for Molecular Food Sciences, Department of Biochemistry, Serbia person Milan Nikolić University of Belgrade, Faculty of Chemistry, Center of Excellence for Molecular Food Sciences, Department of Biochemistry, Serbia person Tanja Ćirković Veličković Serbian Academy of Sciences and Arts, Belgrade, Serbia person Nikola Gligorijević University of Belgrade, Institute for the Application of Nuclear Energy INEP, Serbia person 0000-0002-8691-2486 application/pdf 1374389 https://phaidrabg.bg.ac.rs/o:28418 no yes 16 70 92000001 11A29 11A2905 11A19 11A1903 Antioxidants 12 4 MDPI 2023