o:28081 Sinteza, karakterizacija, antimikrobni i citotoksični efekti kompleksa Mn(II), Zn(II) i Bi(III) sa hidrazonskim derivatima žirarovog P i T reagensa doktorska disertacija Synthesis, characterization, antimicrobial and cytotoxic effects of Mn(II), Cu(II), Zn(II) and Bi(III) complexes with hydrazone derivatives of girard’s reagent P and T : doctoral dissertation sr U ovom radu opisana je sinteza, karakterizacija i kristalna struktura kompleksa 1,nastalog između jona Zn(II) i (E)-1-(2-okso-2-(2-(hinolin-2-ilmetilen)hidrazinil)etil)piridin--ijum-hlorida (HL1Cl) i kompleksa 2, 3, 4 i 5, nastalih između jona Cu(II), Mn(II), Zn(II) iBi(III) sa (E)-N,N,N-trimetil-2-okso-2-(2-(1-(tiazol-2-il)etiliden)hidrazinil)etan-1-aminijumhloridom (HL2Cl). Svi kompleksi okarakterisani su rendgenskom strukturnom analizom,elementalnom analizom i IC spektroskopijom.U slučaju kompleksa 1 ligand HL1Cl koordinovan je u deprotonovanom obliku prekohinolinskog atoma azota, azometinskog atoma azota i karbonilnog atoma kiseonika. LigandHL2Cl u kompleksima 2–4 koordinovan je u deprotonovanom formalno neutralnomcviterjonskom obliku preko NNO donorskog seta atoma, dok u kompleksu 5 ostaje uprotonovanoj formi.Ispitana je antimikrobna aktivnost, test na račićima Artemia salina i DPPH test na svimkompleksima. Antimikrobna aktivnost je ispitana na pet sojeva Gram-pozitivnih i pet sojevaGram-negativnih bakterija, dva soja kvasaca i jednom soju gljivica. Određena je i citotoksičnaaktivnost prema pet malignih ćelijskih linija (HeLa, A375, MCF7, PC-3 i A549) i jednojnormalnoj ćelijskoj liniji (HaCaT). Nije ispitivana citotoksična aktivnost kompleksa 5 uslednjegove hidrolize u rastvoru DMSO.Kompleks 1 pokazao je značajnu antibakterijsku aktivnost posebno premaGram-negativnim bakterijama, sa aktivnošću sličnoj hloramfenikolu, dok je dinuklearnikompleks 3 pokazao antifungalnu aktivnost sličnog intenziteta sa amfotericinom B.Kompleksi 2 i 3 pokazali su značajnu citotoksičnu aktivnost, pri čemu je aktivnost kompleksa3 tek neznatno slabija od one koju pokazuje cisplatin prema ćelijama MCF7. In this work synthesis, characterization and crystal structures of 1, Zn(II) complex([ZnL1(NCS)2]), with (E)-1-(2-oxo-2-(2-(quinolin-2-ylmethylene)hydrazinyl)ethyl)pyridin--1-ium chloride (HL1Cl) and 2, 3, 4 and 5, Cu(II), Mn(II), Zn(II) and Bi(III) complexes with(E)-N,N,N-trimethyl-2-oxo-2-(2-(1-(thiazol-2-yl)ethylidene)hydrazinyl)ethan-1-aminiumchloride (HL2Cl) are represented. All complexes are characterized by X-ray crystallographicanalysis, elemental analysis and IR spectroscopy.In case of complex 1 hydrazone ligand HL1Cl is coordinated in deprotonated formthrough the quinoline nitrogen, azomethine nitrogen and carbonyl oxygen atoms. Hydrazoneligand HL2Cl in complexes 2–4 is coordinated in deprotonated formally neutral zwitter-ionicform via NNO donor set atoms, while in complex 5 it remains in protonated form.Antimicrobial activity, brine shrimp assay and DPPH radical scavenging activity of allcomplexes was evaluated. Antimicrobial activity was tested against a five Gram-negative andfive Gram-positive bacteria, two yeasts and one fungal strain. Cytotoxic activity against fivemalignant cancer cell lines (HeLa, A375, MCF7, PC-3 and A549) and normal cell line HaCaTwas tested as well. Due to hydrolysis that is occurring in DMSO solution of complex 5, thiscomplex was not tested for cytotoxic activity.Complex 1 showed a significant antibacterial activity especially towards Gram-negativebacteria, with intensity similar to chloramphenicol, while the binuclear Mn(II) complex (3)showed antifungal activity of similar intensity as amphotericin B. Complexes 2 and 3 showeda significant cytotoxic activity. The activity of Mn(II) complex (3) is only slightly weaker thanthat of cisplatin against breast cancer MCF7 cells. Hemija - Neorganska hemija / Chemistry - Inorganic chemistry Datum odbrane: 28.09.2022. kompleksi d-metala, kristalna struktura, antimikrobna aktivnost, citotoksični efekat, teorijski proračuni d-metal complexes, crystal structure, antimicrobial activity, cytotoxic effect, theoretical calculations 91552100 108554761 91552101 8988 2023-02-23T10:26:13.053Z 45 no 46 Nevena, 1992- Stevanović 96775945 2022 63 mentor Katarina, 1957- Anđelković 12473191 2022 63 član komisije Božidar, 1983- Čobeljić 32564327 2022 63 član komisije Maja, 1971- Šumar Ristović 14048103 2022 63 član komisije Miroslava, 1961- Vujčić 10884455 2022 111 str. 5251588 http://phaidrabg.bg.ac.rs/o:28081 no yes 1 2023-02-23T10:26:13.320Z 70 kompleksi d-metala, kristalna struktura, antimikrobna aktivnost, citotoksičniefekat, teorijski proračuni. d-metal complexes, crystal structure, antimicrobial activity, cytotoxic effect,theoretical calculations. 546.3/.9:544.25(043.3) 1738 11A19 2022