111 str. 5251588 bytes Sinteza, karakterizacija, antimikrobni i citotoksični efekti kompleksa Mn(II), Zn(II) i Bi(III) sa hidrazonskim derivatima žirarovog P i T reagensa : doktorska disertacija All rights reserved kompleksi d-metala, kristalna struktura, antimikrobna aktivnost, citotoksični efekat, teorijski proračuni d-metal complexes, crystal structure, antimicrobial activity, cytotoxic effect, theoretical calculations 2022 Stevanović, Nevena, 1992- srp Anđelković, Katarina, 1957- Čobeljić, Božidar, 1983- Šumar Ristović, Maja, 1971- Vujčić, Miroslava, 1961- U ovom radu opisana je sinteza, karakterizacija i kristalna struktura kompleksa 1,nastalog između jona Zn(II) i (E)-1-(2-okso-2-(2-(hinolin-2-ilmetilen)hidrazinil)etil)piridin--ijum-hlorida (HL1Cl) i kompleksa 2, 3, 4 i 5, nastalih između jona Cu(II), Mn(II), Zn(II) iBi(III) sa (E)-N,N,N-trimetil-2-okso-2-(2-(1-(tiazol-2-il)etiliden)hidrazinil)etan-1-aminijumhloridom (HL2Cl). Svi kompleksi okarakterisani su rendgenskom strukturnom analizom,elementalnom analizom i IC spektroskopijom.U slučaju kompleksa 1 ligand HL1Cl koordinovan je u deprotonovanom obliku prekohinolinskog atoma azota, azometinskog atoma azota i karbonilnog atoma kiseonika. LigandHL2Cl u kompleksima 2–4 koordinovan je u deprotonovanom formalno neutralnomcviterjonskom obliku preko NNO donorskog seta atoma, dok u kompleksu 5 ostaje uprotonovanoj formi.Ispitana je antimikrobna aktivnost, test na račićima Artemia salina i DPPH test na svimkompleksima. Antimikrobna aktivnost je ispitana na pet sojeva Gram-pozitivnih i pet sojevaGram-negativnih bakterija, dva soja kvasaca i jednom soju gljivica. Određena je i citotoksičnaaktivnost prema pet malignih ćelijskih linija (HeLa, A375, MCF7, PC-3 i A549) i jednojnormalnoj ćelijskoj liniji (HaCaT). Nije ispitivana citotoksična aktivnost kompleksa 5 uslednjegove hidrolize u rastvoru DMSO.Kompleks 1 pokazao je značajnu antibakterijsku aktivnost posebno premaGram-negativnim bakterijama, sa aktivnošću sličnoj hloramfenikolu, dok je dinuklearnikompleks 3 pokazao antifungalnu aktivnost sličnog intenziteta sa amfotericinom B.Kompleksi 2 i 3 pokazali su značajnu citotoksičnu aktivnost, pri čemu je aktivnost kompleksa3 tek neznatno slabija od one koju pokazuje cisplatin prema ćelijama MCF7. In this work synthesis, characterization and crystal structures of 1, Zn(II) complex([ZnL1(NCS)2]), with (E)-1-(2-oxo-2-(2-(quinolin-2-ylmethylene)hydrazinyl)ethyl)pyridin--1-ium chloride (HL1Cl) and 2, 3, 4 and 5, Cu(II), Mn(II), Zn(II) and Bi(III) complexes with(E)-N,N,N-trimethyl-2-oxo-2-(2-(1-(thiazol-2-yl)ethylidene)hydrazinyl)ethan-1-aminiumchloride (HL2Cl) are represented. All complexes are characterized by X-ray crystallographicanalysis, elemental analysis and IR spectroscopy.In case of complex 1 hydrazone ligand HL1Cl is coordinated in deprotonated formthrough the quinoline nitrogen, azomethine nitrogen and carbonyl oxygen atoms. Hydrazoneligand HL2Cl in complexes 2–4 is coordinated in deprotonated formally neutral zwitter-ionicform via NNO donor set atoms, while in complex 5 it remains in protonated form.Antimicrobial activity, brine shrimp assay and DPPH radical scavenging activity of allcomplexes was evaluated. Antimicrobial activity was tested against a five Gram-negative andfive Gram-positive bacteria, two yeasts and one fungal strain. Cytotoxic activity against fivemalignant cancer cell lines (HeLa, A375, MCF7, PC-3 and A549) and normal cell line HaCaTwas tested as well. Due to hydrolysis that is occurring in DMSO solution of complex 5, thiscomplex was not tested for cytotoxic activity.Complex 1 showed a significant antibacterial activity especially towards Gram-negativebacteria, with intensity similar to chloramphenicol, while the binuclear Mn(II) complex (3)showed antifungal activity of similar intensity as amphotericin B. Complexes 2 and 3 showeda significant cytotoxic activity. The activity of Mn(II) complex (3) is only slightly weaker thanthat of cisplatin against breast cancer MCF7 cells. Hemija - Neorganska hemija / Chemistry - Inorganic chemistry Datum odbrane: 28.09.2022. info:eu-repo/semantics/bachelorThesis https://phaidrabg.bg.ac.rs/o:28081 cobiss:108554761 thesis:8988