IL-6, IL-8, inflammation, pregnancy, pregnancy complications International Journal of Molecular Sciences 23(23) 2022 IL-6 and IL-8: an overview of their roles in healthy and pathological pregnancies MDPI application/pdf 954042 bytes http://creativecommons.org/licenses/by/4.0/legalcode info:eu-repo/semantics/article https://phaidrabg.bg.ac.rs/o:27955 doi:10.3390/ijms232314574 ABSTRACT Interleukin-6 (IL-6) is an acknowledged inflammatory cytokine with a pleiotropic action, mediating innate and adaptive immunity and multiple physiological processes, including protective and regenerative ones. IL-8 is a pro-inflammatory CXC chemokine with a primary function in attracting and activating neutrophils, but also implicated in a variety of other cellular processes. These two ILs are abundantly expressed at the feto-maternal interface over the course of a pregnancy and have been shown to participate in numerous pregnancy-related events. In this review, we summarize the literature data regarding their role in healthy and pathological pregnancies. The general information related to IL-6 and IL-8 functions is followed by an overview of their overall expression in cycling endometrium and at the feto-maternal interface. Further, we provide an overview of their involvement in pregnancy establishment and parturition. Finally, the implication of IL-6 and IL-8 in pregnancy-associated pathological conditions, such as pregnancy loss, preeclampsia, gestational diabetes mellitus and infection/inflammation is discussed. eng Vilotić, Aleksandra Jovanović Krivokuća, Milica Dekanski, Dragana Bojić-Trbojević, Žanka Pirković, Andrea Nacka-Aleksić, Mirjana