o:26023 Galectins in early pregnancy and pregnancy-associated pathologies en ABSTRACT Galectins are a family of conserved soluble proteins defined by an affinity for β- galactoside structures present on various glycoconjugates. Over the past few decades, galectins have been recognized as important factors for successful implantation and maintenance of pregnancy. An increasing number of studies have demonstrated their involvement in trophoblast cell function and placental development. In addition, several lines of evidence suggest their important roles in feto-maternal immune tolerance regulation and angiogenesis. Changed or dysregulated galectin expression is also described in pregnancy-related disorders. Although the data regarding galectins clinical relevance are still at an early stage, evidence suggests that some galectin family members are promising candidates for better understanding pregnancy-related pathologies, as well as predicting biomarkers. In this review, we aim to summarize current knowledge of galectins in early pregnancy as well as in pregnancy-related pathologies. galectins, trophoblast function, pregnancy, pregnancy related pathologies 1552099 10.3390/ijms23010069 2022-06-12T17:08:46.946Z 44 yes 46 Milica Jovanović Krivokuća University of Belgrade, Institute for the Application of Nuclear Energy INEP, Serbia doktor bioloških nauka 0000-0001-8292-4853 Žanka Bojić-Trbojević University of Belgrade, Institute for the Application of Nuclear Energy INEP, Serbia doktor bioloških nauka person 0000-0001-5619-1027 Dragana Dekanski University of Belgrade, Institute for the Application of Nuclear Energy INEP, Serbia doktor medicinskih nauka person 0000-0001-8467-4165 Janko Legner University of Belgrade, Institute for the Application of Nuclear Energy INEP, Serbia person Danica Ćujić University of Belgrade, Institute for the Application of Nuclear Energy INEP, Serbia doktor medicinskih nauka-farmacija person 0000-0002-6145-3850 Andrea Pirković University of Belgrade, Institute for the Application of Nuclear Energy INEP, Serbia doktor bioloških nauka person 0000-0002-1182-4895 Mirjana Nacka-Aleksić University of Belgrade, Institute for the Application of Nuclear Energy INEP, Serbia doktor medicinskih nauka-farmacija person 0000-0003-0750-9347 Aleksandra Vilotić University of Belgrade, Institute for the Application of Nuclear Energy INEP, Serbia doktor bioloških nauka person 0000-0002-0898-5401 application/pdf 1117266 https://phaidrabg.bg.ac.rs/o:26023 no yes 16 70 92000001 11A29 11A2901 International Journal of Molecular Sciences 23 1 MDPI 2021