o:25843 Role of resveratrol in prevention and control of cardiovascular disorders and cardiovascular complications related to COVID-19 disease: mode of action and approaches explored to increase its bioavailability Uloga rezveratrola u prevenciji i kontroli kardiovaskularnih oboljenja i kardiovaskularnih komplikacija povezanim sa COVID-19: načini delovanja i mogućnosti povećanja njegove biodostupnosti en ABSTRACT Resveratrol is a phytoalexin produced by many plants as a defense mechanism against stress-inducing conditions. The richest dietary sources of resveratrol are berries and grapes, their juices and wines. Good bioavailability of resveratrol is not reflected in its high biological activity in vivo because of resveratrol isomerization and its poor solubility in aqueous solutions. Proteins, cyclodextrins and nanomaterials have been explored as innovative delivery vehicles for resveratrol to overcome this limitation. Numerous in vitro and in vivo studies demonstrated beneficial effects of resveratrol in cardiovascular diseases (CVD). Main beneficial effects of resveratrol intake are cardioprotective, anti-hypertensive, vasodilatory, anti-diabetic, and improvement of lipid status. As resveratrol can alleviate the numerous factors associated with CVD, it has potential as a functional supplement to reduce COVID-19 illness severity in patients displaying poor prognosis due to cardio-vascular complications. Resveratrol was shown to mitigate the major pathways involved in the pathogenesis of SARS-CoV-2 including regulation of the renin-angiotensin system and expression of angiotensin-converting enzyme 2, stimulation of immune system and downregulation of pro- inflammatory cytokine release. Therefore, several studies already have anticipated potential implementation of resveratrol in COVID-19 treatment. Regular intake of a resveratrol rich diet, or resveratrol-based complementary medicaments, may contribute to a healthier cardio-vascular system, prevention and control of CVD, including COVID-19 disease related complications of CVD. resveratrol, cardiovascular disease, bioavailability, diet, COVID-19, resveratrol carriers, cardiovascular protection 1552099 10.3390/molecules26102834 2022-06-01T06:29:45.914Z 44 yes 46 Nikola Gligorijević University of Belgrade, Institute for the Application of Nuclear Energy INEP, Serbia doktor biohemijskih nauka 0000-0002-8691-2486 Tanja Ćirković-Veličković University of Belgrade, Faculty of Chemistry, Center of Excellence for Molecular Food Sciences, Department of Biochemistry, Serbia person Olgica Nedić University of Belgrade, Institute for the Application of Nuclear Energy INEP, Serbia doktor biohemijskih nauka person 0000-0003-2042-0056 Urmila Khulal Ghent University, Faculty of Bioscience Engineering, Belgium person Marija Stojadinović University of Belgrade, Faculty of Chemistry, Center of Excellence for Molecular Food Sciences, Department of Biochemistry, Serbia person Mirjana Radomirović University of Belgrade, Faculty of Chemistry, Center of Excellence for Molecular Food Sciences, Department of Biochemistry, Serbia person Dragana Stanić-Vučinić University of Belgrade, Faculty of Chemistry, Center of Excellence for Molecular Food Sciences, Department of Biochemistry, Serbia person application/pdf 2432634 https://phaidrabg.bg.ac.rs/o:25843 no yes 16 70 92000001 11A29 11A2905 11A19 11A1903 Molecules 26 MDPI 2021