o:25841 Ligand binding to fibrinogen influences its structure and function Vezivanje liganada za fibrinogen utiče na njegovu strukturu i funkciju en ABSTRACT Fibrinogen is a plasma protein that is highly susceptible to oxidation. Because of this chemical modification, fibrinogen acquires thrombogenic characteristics under different pathophysiological conditions. Increased carbonyl content and reduced porosity impair the degradation of formed fibrin mediated by plasmin. Fibrinogen is capable of interacting with many proteins, ions, and small molecules. These interactions can modify the functions of this protein. The discovery of new binding partners that may protect fibrinogen from harmful oxidation and, thus, preserve its normal function is essential. Some of the newly detected interactions between fibrinogen and small, natural bioactive molecules, together with the influence of these interactions on the structure and function of fibrinogen, will be presented in this text. bilirubin, dihydrolipoic acid, fibrinogen, protein function, protein-ligand interaction, protein structure, resveratrol 1552099 10.5281/zenodo.5512285 2022-05-31T19:56:48.149Z 44 yes 46 Nikola Gligorijević University of Belgrade, Institute for the Application of Nuclear Energy INEP, Serbia doktor biohemijskih nauka 0000-0002-8691-2486 Olgica Nedić University of Belgrade, Institute for the Application of Nuclear Energy INEP, Serbia doktor biohemijskih nauka person 0000-0003-2042-0056 Tanja Ćirković Veličković University of Belgrade, Faculty of Chemistry, Center of Excellence for Molecular Food Sciences, Department of Biochemistry, Serbia person Milan Nikolić University of Belgrade, Faculty of Chemistry, Center of Excellence for Molecular Food Sciences, Department of Biochemistry, Serbia person Steva Lević University of Belgrade, Faculty of Agriculture, Serbia person Mirjana Radomirović University of Belgrade, Faculty of Chemistry, Center of Excellence for Molecular Food Sciences, Department of Biochemistry, Serbia person Simeon Minić University of Belgrade, Faculty of Chemistry, Center of Excellence for Molecular Food Sciences, Department of Biochemistry, Serbia person application/pdf 4265378 https://phaidrabg.bg.ac.rs/o:25841 no yes 16 70 92000001 11A29 11A2905 11A19 11A1903 11A33 Biologia Serbica 43 1 24 31 2021