o:25839 Molecular mechanisms of possible action of phenolic compounds in COVID-19 protection and prevention Molekulski mehanizmi mogućih dejstava fenolnih jedinjenja u zaštiti i prevenciji Kovida-19 en ABSTRACT The worldwide outbreak of COVID-19 was caused by a pathogenic virus called Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). Therapies against SARS-CoV-2 target the virus or human cells or the immune system. However, therapies based on specific antibodies, such as vaccines and monoclonal antibodies, may become inefficient enough when the virus changes its antigenicity due to mutations. Polyphenols are the major class of bioactive compounds in nature, exerting diverse health effects based on their direct antioxidant activity and their effects in the modulation of intracellular signaling. There are currently numerous clinical trials investigating the effects of polyphenols in prophylaxis and the treatment of COVID-19, from symptomatic, via moderate and severe COVID-19 treatment, to anti-fibrotic treatment in discharged COVID-19 patients. Antiviral activities of polyphenols and their impact on immune system modulation could serve as a solid basis for developing polyphenol-based natural approaches for preventing and treating COVID-19. SARS-CoV-2, polyphenols, antiviral effects, antiviral targets 1552099 10.3390/ijms222212385 2022-05-31T18:07:42.038Z 44 yes 46 Nikola Gligorijević University of Belgrade, Institute for the Application of Nuclear Energy INEP, Serbia doktor biohemijskih nauka 0000-0002-8691-2486 Tanja Ćirković-Veličković University of Belgrade, Faculty of Chemistry, Center of Excellence for Molecular Food Sciences, Department of Biochemistry, Serbia person Dragana Stanić-Vučinić University of Belgrade, Faculty of Chemistry, Center of Excellence for Molecular Food Sciences, Department of Biochemistry, Serbia person Urmila Khulal Ghent University, Faculty of Bioscience Engineering, Belgium person Marija Stojadinović University of Belgrade, Faculty of Chemistry, Center of Excellence for Molecular Food Sciences, Department of Biochemistry, Serbia person Olgica Nedić University of Belgrade, Institute for the Application of Nuclear Energy INEP, Serbia doktor biohemijskih nauka person 0000-0003-2042-0056 Mirjana Radomirović University of Belgrade, Faculty of Chemistry, Center of Excellence for Molecular Food Sciences, Department of Biochemistry, Serbia person application/pdf 2637134 https://phaidrabg.bg.ac.rs/o:25839 no yes 16 70 92000001 11A29 11A2905 11A19 11A1903 International Journal of Molecular Sciences 22 22 MDPI 2021