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    <ns1:title language="en">Extracellular vesicles and renal fibrosis: an Odyssey toward a new therapeutic approach</ns1:title>
    <ns1:language>en</ns1:language>
    <ns1:description language="en">ABSTRACT
Renal fibrosis is a complex disorder characterized by the destruction of kidney parenchyma. There is currently no cure for this devastating condition. Extracellular vesicles (EVs) are membranous vesicles released from cells in both physiological and diseased states. Given their fundamental role in transferring biomolecules to recipient cells and their ability to cross biological barriers, EVs have been widely investigated as potential cell-free therapeutic agents. In this review, we provide an overview of EVs, focusing on their functional role in renal fibrosis and signaling messengers responsible for
EV-mediated crosstalk between various renal compartments. We explore recent findings regarding the renoprotective effect of EVs and their use as therapeutic agents in renal fibrosis. We also highlight
advantages and future perspectives of the therapeutic applications of EVs in renal diseases.</ns1:description>
    <ns1:keyword language="en">CKD, cell-free therapeutic, cellular communication, exosomes, extracellular vesicles, mesenchymal stem cells, regeneration, renal fibrosis, renoprotection, therapeutic agents</ns1:keyword>
    <ns2:identifiers>
      <ns2:resource>1552099</ns2:resource>
      <ns2:identifier>10.3390/ijms22083887</ns2:identifier>
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    <ns1:upload_date>2022-05-23T17:11:24.752Z</ns1:upload_date>
    <ns1:status>44</ns1:status>
    <ns2:peer_reviewed>yes</ns2:peer_reviewed>
    <ns1:contribute seq="0">
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        <ns3:firstname>Maja</ns3:firstname>
        <ns3:lastname>Kosanović</ns3:lastname>
        <ns3:institution>University of Belgrade, Institute for the Application of Nuclear Energy INEP, Serbia</ns3:institution>
        <ns3:title1>doktor bioloških nauka</ns3:title1>
        <ns3:orcid>0000-0002-1143-1805</ns3:orcid>
      </ns1:entity>
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        <ns3:firstname>Milica</ns3:firstname>
        <ns3:lastname>Božić</ns3:lastname>
        <ns3:institution>Vascular and Renal Translational Research Group, Institute for Biomedical Research in Lleida (IRBLleida) and RedInRen RETIC, Spain</ns3:institution>
        <ns3:type>person</ns3:type>
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        <ns3:firstname>José M.</ns3:firstname>
        <ns3:lastname>Valdivielso</ns3:lastname>
        <ns3:institution>Vascular and Renal Translational Research Group, Institute for Biomedical Research in Lleida (IRBLleida) and RedInRen RETIC, Spain</ns3:institution>
        <ns3:type>person</ns3:type>
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        <ns3:firstname>Sofija</ns3:firstname>
        <ns3:lastname>Glamočlija</ns3:lastname>
        <ns3:institution>University of Belgrade, Institute for the Application of Nuclear Energy INEP, Serbia</ns3:institution>
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        <ns3:orcid>0000-0003-0497-5852</ns3:orcid>
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        <ns3:firstname>Alicia</ns3:firstname>
        <ns3:lastname>Llorente</ns3:lastname>
        <ns3:institution>Oslo University Hospital, Institute for Cancer Research, Department of Molecular Cell Biology, Norway</ns3:institution>
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    <ns1:location>https://phaidrabg.bg.ac.rs/o:25587</ns1:location>
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  <ns12:digitalbook>
    <ns12:name_magazine language="en">International Journal of Molecular Sciences</ns12:name_magazine>
    <ns12:volume>22</ns12:volume>
    <ns12:booklet>8</ns12:booklet>
    <ns12:from_page>3887</ns12:from_page>
    <ns12:publisher>MDPI</ns12:publisher>
    <ns12:releaseyear>2021</ns12:releaseyear>
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