o:25425 Biocompatible Iron-Boron Nanoparticles Designed for Neutron Capture Therapy Guided by Magnetic Resonance Imaging Biokompatibilne nanočestice gvožđe-bor dizajnirane za terapiju hvatanja neutrona vođenu magnetnom rezonancom en ABSTRACT The combination of multiple functions in a single nanoparticle (NP) represents a key advantage of nanomedicine compared to traditional medical approaches. This is well represented by radiotherapy in which the dose of ionizing radiation should be calibrated on sensitizers biodistribution. Ideally, this is possible when the drug acts both as radiation enhancer and imaging contrast agent. Here, an easy, one-step, laser-assisted synthetic procedure is used to generate iron-boron (Fe-B) NPs featuring the set of functions required to assist neutron capture therapy (NCT) with magnetic resonance imaging. The Fe-B NPs exceed by three orders of magnitude the payload of boron isotopes contained in clinical sensitizers. The Fe-B NPs have magnetic properties of interest also for magnetophoretic accumulation in tissues and magnetic hyperthermia to assist drug permeation in tissues. Besides, Fe-B NPs are biocompatible and undergo slow degradation in the lysosomal environment that facilitates in vivo clearance through the liver-spleen-kidneys pathway. Overall, the Fe-B NPs represent a new promising tool for future exploitation in magnetic resonance imaging-guided boron NCT at higher levels of efficacy and tolerability. Sažetak bimetallic nanoparticles, boron neutron capture therapy, laser ablation, magnetic nanoparticles, magnetic resonance imaging 1552099 10.1002/adhm.202001632 2022-05-17T08:27:38.025Z 44 yes 46 Veronica Torresan University of Padova, Department of Chemical Sciences, Italy Vincenzo Amendola University of Padova, Department of Chemical Sciences, Italy person Pasquina Marzola University of Verona, Department of Computer Science, Italy person Alice Busato University of Verona, Department of Computer Science, Italy person Marco Gerosa University of Verona, Department of Computer Science, Italy person Miodrag Čolić University of Belgrade, Institute for the Application of Nuclear Energy INEP, Serbia akademik person Marina Bekić University of Belgrade, Institute for the Application of Nuclear Energy INEP, Serbia person 0000-0002-6945-4241 Silva Bortolussi INFN (National Institute of Nuclear Physics) Pavia, Italy person Ian Postuma INFN (National Institute of Nuclear Physics) Pavia, Italy person Marcela B Fernàndez van Raap National University of La Plata, Physics Institute of La Plata (IFLP-CONICET), Physics Department, Faculty of Exact Sciences, Argentina person Guillermo Arturo Muñoz Medina National University of La Plata, Physics Institute of La Plata (IFLP-CONICET), Physics Department, Faculty of Exact Sciences, Argentina person Paolo Pastore University of Padova, Department of Chemical Sciences, Italy person Denis Badocco University of Padova, Department of Chemical Sciences, Italy person Andrea Guadagnini University of Padova, Department of Chemical Sciences, Italy person application/pdf 5947 https://phaidrabg.bg.ac.rs/o:25425 no yes 1 70 92000001 11A29 11A2904 Advanced Healthcare Materials 10 6 Wiley-VCH GmbH 2021