o:25299 Association between genetic variants in DICER1 and cancer risk: An updated meta-analysis Asocijacija varijanti u genu DICER1 sa rizikom za razvoj malignih bolesti: dopunjena meta-analiza en ABSTRACT Dysfunctions in mechanisms of gene regulation based on RNA interference are recognized as a common feature of the molecular basis of cancer pathogenesis. Therefore, as one of the crucial components of the machinery involved in the biogenesis of both siRNAs and microRNA molecules, DICER was recognized as one of the candidates for the research in the field of carcinogenesis. Due to their potential functional properties, several genetic variants located within DICER1 gene were analyzed for their possible association with the susceptibility to cancer through case-control studies. In order to elucidate their effect on the overall cancer risk, we conducted an updated meta-analysis of all eligible association studies. The publications were selected based on PubMed database search, while OpenMeta-analyst and MetaGenyo software were used for quantitative data synthesis. Statistically significant results were found for the association of rs1057035 with the overall cancer risk under multiple genetic models (PCT vs. TT < 0.001, ORCT vs. TT = 0.870, 95% CI = 0.812-0.933; Pallelic = 0.009, ORallelic = 0.896, 95% CI = 0.825-0.973; Pdom < 0.001, ORdom = 0.874, 95% CI = 0.817-0.934; Poverdom = 0.004, ORoverdom = 0.858, 95% CI = 0.773-0.953). Other selected genetic variants within DICER1, rs13078, rs1209904 and rs3742330, did not show the association with the overall susceptibility to malignant diseases. We conclude that rs1057035 may represent a potential biomarker associated with the risk of developing cancer, which requires a confirmation in a larger set of studies. Sažetak cancer, DICER1, genetic variant, rs1057035, rs13078, rs3742330 1552099 10.1016/j.gene.2020.145132 2022-05-11T18:50:43.019Z 44 yes 46 Zorana Dobrijević University of Belgrade, Institute for the Application of Nuclear Energy INEP, Serbia doktor bioloških nauka 0000-0002-4652-7719 Suzana Matijašević University of Belgrade, Faculty of Biology, Centre for Human Molecular Genetics, Serbia person Tijana Išić Denčić University of Belgrade, Institute for the Application of Nuclear Energy INEP, Serbia doktor bioloških nauka person 0000-0001-8475-2266 Dušanka Savić-Pavićević University of Belgrade, Faculty of Biology, Centre for Human Molecular Genetics, Serbia person Olgica Nedić University of Belgrade, Institute for the Application of Nuclear Energy INEP, Serbia doktor biohemijskih nauka person 0000-0003-2042-0056 Goran Brajušković University of Belgrade, Faculty of Biology, Centre for Human Molecular Genetics, Serbia person application/pdf 9739 https://phaidrabg.bg.ac.rs/o:25299 no yes 1 70 92000001 11A29 11A2905 11A29 11A2902 11A02 Gene 766 Elsevier 2021