o:17567 Određivanje anizomicina tečnom hromatografijom sa tandem masenom spektrometrijom i elektrohemijskim metodama i primena na ispitivanje stabilnosti leka i njegove raspodele u tkivima pacova doktorska disertacija Determination of anisomycin by liquid chromatography with tandem mass spectrometry and electrochemical methods and application to investigation of drug stability and its distribution in rat tissues : doctoral dissertation sr Lek anizomicin je potencijalni imunosupresor pri niskim dozama (≤ 0,1 μM). TakoĎe ima potencijalnu primenu kao psihofarmaceutik i antikancerogeni lek, a u novijim istraţivanjima se pokazalo da je potencijalni radioprotektor. I pored višestruke potencijalne primene anizomicina, još uvek nema podataka o njegovoj kliničkoj primeni. Zbog toga je potrebno poznavanje farmakokinetičkih svojstava leka, pre svega poznavanje principa raspodele leka u organizmu i najznačajnijih farmakokinetičkih parametara. TakoĎe, da bi se utvrdio kvalitet leka i bezbednost njegovog korišćenja, potrebno je pratiti stabilnost i odrediti degradacione proizvode koji mogu nastati tokom proizvodnje, rukovanja ili čuvanja leka... Drug anisomycin is a potential immunosuppressant in low doses (≤ 0.1 μM). It also has the potential use as a psychopharmaceutical and an anticancerous drug, and in the recent investigations it was shown that it is a potential radioprotector. Despite of multiple potential applications of anisomysin, its clinical use has not been reported yet. In that order, it is necessary to understand the pharmacokinetic properties of the drug, primarily its body distribution and the most important pharmacokinetic parameters. Also, in order to establish quality of the drug and safety of its use, it is required to monitor its stability and to determine its degradation products that may be formed during production, handling or storage... Hemijske nauke / Chemical sciences Datum odbrane: 09.03.2018. anizomicin, tečna hromatografija–tandem masena spektrometrija, elektrohemijske metode, biološki materijal, raspodela leka u tkivima, farmakokinetički parametri, forsirana degradacija anisomycin, liquid chromatography–tandem mass spectrometry, electrochemical methods, biological material, tissue distribution of the drug, pharmacokinetic parameters, forced degradation yes 50003215 91552101 5745 91552100 50003215 2018-04-23T14:19:24.053Z 45 no 46 mentor Ljiljana M., 1986- Tolić 2017 63 mentor Mila, 1951- Laušević 2017 63 član komisije Svetlana, 1973- Grujić 2017 63 član komisije Slobodan, 1950- Petrović 2017 63 član komisije Slavica, 1960- Ražić 2017 63 član komisije Branislava, 1963- Miljković 2017 122 lista 5567672 http://phaidrabg.bg.ac.rs/o:17567 no yes 4 2018-04-23T14:19:24.320Z 70 11 1067197 1067378 1067387 11 1067094 1067105 anizomicin, tečna hromatografija–tandem masena spektrometrija, elektrohemijske metode, biološki materijal, raspodela leka u tkivima, farmakokinetički parametri, forsirana degradacija anisomycin, liquid chromatography–tandem mass spectrometry, electrochemical methods, biological material, tissue distribution of the drug, pharmacokinetic parameters, forced degradation 1738 11A41 2017