o:16791 Interakcija bipiridinskih kompleksa zlata(III) i polioksovolframata sa Na+/K+-ATPazom i acetilholinesterazom doktorska disertacija The interaction of bipyridyl gold(III) complexes and polyoxotungstates with Na+/K+-ATPaze and acetylcholinesterase : doctoral dissertation sr U ovoj doktorskoj disertaciji ispitan je uticaj antitumorskih mononuklearnih i binuklearnih kompleksa zlata(III) (AubipyC, Aubipy(OH)2, Aupy(OAc)2, Auoxo6, Au2bipyC i Au2phen) na Na+/K+-ATPazu, kao i uticaj polioksometalata, 12- volframsilicijumove i 12-volframfosforne kiseline (WSiA i WPA) na acetilholinesterazu (AChE). Primenom različitih fizičkohemijskih metoda (UV/Vis i fluorescentna spektroskopija, cirkularni dihroizam, elektronska paramagnetna rezonantna (EPR) spektroskopija) u kombinaciji sa molekulskim modelovanjem, dobijen je detaljan uvid u njihovu interakciju na molekulskom nivou. Ispitivanjem uticaja ovih jedinjenja na antioksidativne enzime i na nivo malondialdehida, procenjeni su njihovi toksični potencijali, a merenjem učestalosti mikronukleusa i indeksa ćelijske proliferacije procenjeni su njihovi genotoksični i citotoksični efekti... In this doctoral dissertation, the interaction of antitumor mononuclear and binuclear gold(III) complexes (AubipyC, Aubipy(OH)2, Aupy(OAc)2, Auoxo6, Au2bipyC and Au2phen) with Na+/K+-ATPas,e as well as the interaction of polioxotungstates, 12- tungstosilicic acid and 12-tungstophosphoric acid (WSiA and WPA), with acetylholinesterase have been investigated. Various spectroscopic methods (UV/Vis and fluorescent spectroscopy, circular dichroism, electron paramagnetic resonance (EPR) spectroscopy) in combination with docking studies were used in order to obtain detailed insight into their interaction on the molecular level. By investigating the influence of these compounds on the antioxidative enzymes and the level of malondialdehyde, their toxic potentials were evaluated. Furthermore, their genotoxic and cytotoxic effects were estimated by measuring the incidence of micronuclei and the cytokinesis-block proliferation index in human lymphocyte cultures... Fizička hemija - Biofizička hemija / Physical chemistry - Biophysical chemistry Datum odbrane: 3.11.2017 kompleksi zlata, Na+/K+-ATPaza, polioksovolframati, acetilholinesteraza,fluorescentna spektroskopija, cirkularni dihroizam, EPR spektroskopija, oksidativnistres, genotoksičnost, citotoksičnost gold complexes, Na+/K+-ATPase, polioxotungstates, acetylholinesterase,fluorescent spectroscopy, circular dichroism, EPR spectroscopy, oxidative stress,genotoxicity, citotoxicity yes 49630735 91552101 5416 91552100 49630735 2017-12-11T14:54:48.053Z 45 no 46 mentor Aleksandra, 1981- Bondžić 2017 63 mentor Ana, 1976- Popović-Bijelić 2017 63 mentor Vesna Vasić 2017 63 član komisije Miloš, 1973- Mojović 2017 63 član komisije Mirjana Čolović 2017 172 lista 4792151 http://phaidrabg.bg.ac.rs/o:16791 no yes 4 2017-12-11T14:54:48.320Z 70 11 1066775 1066784 1066785 kompleksi zlata, Na+/K+-ATPaza, polioksovolframati, acetilholinesteraza,fluorescentna spektroskopija, cirkularni dihroizam, EPR spektroskopija, oksidativnistres, genotoksičnost, citotoksičnost gold complexes, Na+/K+-ATPase, polioxotungstates, acetylholinesterase,fluorescent spectroscopy, circular dichroism, EPR spectroscopy, oxidative stress,genotoxicity, citotoxicity 1738 11A11 2017