
<ns0:uwmetadata xmlns:ns0="http://phaidra.univie.ac.at/XML/metadata/V1.0" xmlns:ns1="http://phaidra.univie.ac.at/XML/metadata/lom/V1.0" xmlns:ns10="http://phaidra.univie.ac.at/XML/metadata/provenience/V1.0" xmlns:ns11="http://phaidra.univie.ac.at/XML/metadata/provenience/V1.0/entity" xmlns:ns12="http://phaidra.univie.ac.at/XML/metadata/digitalbook/V1.0" xmlns:ns13="http://phaidra.univie.ac.at/XML/metadata/etheses/V1.0" xmlns:ns2="http://phaidra.univie.ac.at/XML/metadata/extended/V1.0" xmlns:ns3="http://phaidra.univie.ac.at/XML/metadata/lom/V1.0/entity" xmlns:ns4="http://phaidra.univie.ac.at/XML/metadata/lom/V1.0/requirement" xmlns:ns5="http://phaidra.univie.ac.at/XML/metadata/lom/V1.0/educational" xmlns:ns6="http://phaidra.univie.ac.at/XML/metadata/lom/V1.0/annotation" xmlns:ns7="http://phaidra.univie.ac.at/XML/metadata/lom/V1.0/classification" xmlns:ns8="http://phaidra.univie.ac.at/XML/metadata/lom/V1.0/organization" xmlns:ns9="http://phaidra.univie.ac.at/XML/metadata/histkult/V1.0">
  <ns1:general>
    <ns1:identifier>o:12613</ns1:identifier>
    <ns1:title language="sr">Analiza hromozomske translokacije T(11;19) kod mukoepidermoidnog karcinoma pljuvačnih žlezda - korelacija sa kliničkim i histopatološkim parametrima</ns1:title>
    <ns2:subtitle language="sr">doktorska disertacija</ns2:subtitle>
    <ns2:alt_title language="en">Analysis of chromosomal translocation T(11;19) in mucoepidermoid carcinoma of salivary glands - correlation with clinical and histopathological parameters  : doctoral dissertation</ns2:alt_title>
    <ns1:language>sr</ns1:language>
    <ns1:description language="sr">Kod velikog broja salivarnih mukoepidermoidnih karcinoma (MEK) detektovana je rekurentna t(11;19) hromozoska translokacija čiji je proizvod novostvoreni fuzio onkogen (MECT1-MAML2). Prisustvo MECT1-MAML2 onkogena remeti normalan ćelijski ciklus i ćelijsku diferencijaciju, dovodeći do nastanka i razvoja tumora. Ciljevi ove studije bili su da se utvrdi incidenca MECT1-MAML2 fuzije kod srpskih pacijenata, zatim da se ispita odnos MECT1-MAML2 fuzije sa kliničkim i histopatološkim karakteristikama MEK-a, kao i da se utvrdi relevantnost ove fuzije kao molekularnog markera biološkog ponašanja MEK-a. U ovoj retrospektivnoj studiji, 20 slučajeva MEK-a i 23 slučajeva MEK-ovih imitacija je bilo testirano na prisustvo MECT1-MAML2 fuzije koristeći reverznu transkriptazu-polimeraznu lančanu reakciju (RT-PCR). Klinički i histopatološki parametri zajedno sa preživljavanjem bez znakova bolesti i ukupnim vremenom preživljavanja su ispitivani u odnosu na MECT1-MAML2 fuzioni status. MEK imitacije (n=23) su definisane kao ne-MEK grupa i svi slučajevi ovih karcinoma su bili negativni na MECT1-MAML2 fuziju. Kod MEK-a (n=20) fuzija je bila detektovana u 8 slučajeva (40%). Prisustvo MECT1-MAML2 fuzije je bilo povezano sa niskim histološkim gradusom tumora (P = 0.02), sa preživljavanjem bez znakova bolesti (P= 0.002) i ukupnim vremenom preživljavanja (P=0.046). Ova studija je pokazala da su LG fuzio-pozitivni MEK-i poseban kliničko-histopatološki entitet, zatim
da MECT1-MAML2 fuzija može da se koristi kao pomoćni dijagnostički i prognostički marker za mukoepidermoidni karcinom.
</ns1:description>
    <ns1:description language="en">A significant number of salivary mucoepidermoid carcinoma (MEC) harbor a recurring t(11;19) translocation with an associated novel fusion oncogene (MECT1-MAML2). The MECT1-MAML2 oncogene disrupts normal cell-cycle and differentiation, contributing to tumor development. The objectives of this study were to establish the incidence of MECT1-MAML2 fusion in Serbian patients, to examine the correlation between MECT1-MAML2 status and clinico-pathological parameters of MECs, and estimate its relevance as a genetic marker of MEC behavior. In this retrospective study, 20 cases of MEC of salivary glands and 23 cases of MEC mimics were tested for the presence of MECT1-MAML2 fusion using reverse transcriptase-polymerase chain reaction (RT-PCR). Histopatological as well as clinical parameters, disease free survival, and overall survival data were examined in relation to fusion status. MEC mimics (n=23) were defined as non-MECs and all these cases were negative for the MECT1-MAML2 fusion. In the group of confirmed MECs (n=20) the MECT1-MAML2 fusion was detected in 8 cases (40%). The presence of the MECT1-MAML2 fusion was associated with low-grade tumor histology (P = 0.02), with disease-free survival (P= 0.002) and with overall survival rate (P=0.046). The study has shown that the LG fusio-positive MECs represent unique clinico-histopatological entity, as well as that
the presence of the MECT1-MAML2 fusion can serve as an additional diagnostic and prognostic marker for mucoepidermoid carcinomas.
</ns1:description>
    <ns1:description language="sr">Stomatologija / Dentistry  
Datum odbrane: 07.04.2016. </ns1:description>
    <ns1:keyword language="sr">Karcinomi pljuvačnih žlezda, Mukoepidermoidni karcinom, Hromozomska translokacija t(11, 19), MECT1-MAML2, PCR dijagnostika</ns1:keyword>
    <ns1:keyword language="en">Salivary gland, Mucoepidermoid carcinoma, Chromosomal translocation t(11,19), MECT1-MAML2, RT-PCR diagnostic</ns1:keyword>
    <ns1:keyword language="sr">616.316-006.6:577.2(043.3)</ns1:keyword>
    <ns2:irdata>yes</ns2:irdata>
    <ns2:identifiers>
      <ns2:identifier>48127759</ns2:identifier>
    </ns2:identifiers>
    <ns2:identifiers>
      <ns2:resource>91552101</ns2:resource>
      <ns2:identifier>3749</ns2:identifier>
    </ns2:identifiers>
    <ns2:identifiers>
      <ns2:resource>91552100</ns2:resource>
      <ns2:identifier>48127759</ns2:identifier>
    </ns2:identifiers>
  </ns1:general>
  <ns1:lifecycle>
    <ns1:upload_date>2016-08-30T10:38:05.053Z</ns1:upload_date>
    <ns1:status>45</ns1:status>
    <ns2:peer_reviewed>no</ns2:peer_reviewed>
    <ns1:contribute seq="0">
      <ns1:role>46</ns1:role>
      <ns1:ext_role>mentor</ns1:ext_role>
      <ns1:entity seq="0">
        <ns3:firstname> Ivana J., 1982- </ns3:firstname>
        <ns3:lastname>Ilić-Dimitrijević</ns3:lastname>
      </ns1:entity>
      <ns1:date>2014</ns1:date>
    </ns1:contribute>
    <ns1:contribute seq="1">
      <ns1:role>63</ns1:role>
      <ns1:ext_role>mentor</ns1:ext_role>
      <ns1:entity seq="0">
        <ns3:firstname> Vitomir, 1961- </ns3:firstname>
        <ns3:lastname>Konstantinović</ns3:lastname>
      </ns1:entity>
      <ns1:date>2014</ns1:date>
    </ns1:contribute>
    <ns1:contribute seq="2">
      <ns1:role>63</ns1:role>
      <ns1:ext_role>član komisije</ns1:ext_role>
      <ns1:entity seq="0">
        <ns3:firstname> Milan, 1967- </ns3:firstname>
        <ns3:lastname>Petrović</ns3:lastname>
      </ns1:entity>
      <ns1:date>2014</ns1:date>
    </ns1:contribute>
    <ns1:contribute seq="3">
      <ns1:role>63</ns1:role>
      <ns1:ext_role>član komisije</ns1:ext_role>
      <ns1:entity seq="0">
        <ns3:firstname> Zvezdana, 1963- </ns3:firstname>
        <ns3:lastname>Tepavčević</ns3:lastname>
      </ns1:entity>
      <ns1:date>2014</ns1:date>
    </ns1:contribute>
    <ns1:contribute seq="4">
      <ns1:role>63</ns1:role>
      <ns1:ext_role>član komisije</ns1:ext_role>
      <ns1:entity seq="0">
        <ns3:firstname> Ivana, 1961- </ns3:firstname>
        <ns3:lastname>Novaković</ns3:lastname>
      </ns1:entity>
      <ns1:date>2014</ns1:date>
    </ns1:contribute>
  </ns1:lifecycle>
  <ns1:technical>
    <ns1:format>XXIII, 133 lista</ns1:format>
    <ns1:size>2667424</ns1:size>
    <ns1:location>http://phaidrabg.bg.ac.rs/o:12613</ns1:location>
  </ns1:technical>
  <ns1:rights>
    <ns1:cost>no</ns1:cost>
    <ns1:copyright>yes</ns1:copyright>
    <ns1:license>4</ns1:license>
  </ns1:rights>
  <ns1:annotation>
    <ns6:annotations>
      <ns6:date>2016-08-30T10:38:05.320Z</ns6:date>
    </ns6:annotations>
  </ns1:annotation>
  <ns1:classification>
    <ns1:purpose>70</ns1:purpose>
    <ns7:taxonpath>
      <ns7:source>11</ns7:source>
      <ns7:taxon seq="0">1067044</ns7:taxon>
    </ns7:taxonpath>
    <ns7:description language="sr">Stomatologija / Dentistry  </ns7:description>
    <ns7:keyword language="sr" seq="0">Karcinomi pljuvačnih žlezda, Mukoepidermoidni karcinom, Hromozomska translokacija t(11, 19), MECT1-MAML2, PCR dijagnostika</ns7:keyword>
    <ns7:keyword language="en" seq="1">Salivary gland, Mucoepidermoid carcinoma, Chromosomal translocation t(11,19), MECT1-MAML2, RT-PCR diagnostic</ns7:keyword>
    <ns7:keyword language="sr" seq="2">616.316-006.6:577.2(043.3)</ns7:keyword>
  </ns1:classification>
  <ns1:organization>
    <ns8:hoschtyp>1738</ns8:hoschtyp>
    <ns8:orgassignment>
      <ns8:faculty>11A38</ns8:faculty>
    </ns8:orgassignment>
  </ns1:organization>
  <ns12:digitalbook>
    <ns12:releaseyear>2014</ns12:releaseyear>
  </ns12:digitalbook>
</ns0:uwmetadata>